GFR determination in adults with a single-sample iohexol plasma clearance method based on the mean sojourn time
نویسندگان
چکیده
منابع مشابه
Licentiate Dissertation in Medical Science
4 ORIGINAL PAPERS 5 ABBREVIATIONS 6 INTRODUCTION 7 Marker substances for GFR 8 Endogenous markers 8 Exogenous markers 8 Clearance techniques for determination of GFR 9 Continuous infusion method 9 Single injection method 10 Single injection, single sample methods 12 AIMS OF THE STUDY 16 MATERIALS AND METHODS 17 Materials 17 Cr-EDTA and Tc-DTPA analysis 18 Iohexol analysis 19 Derivation of a sin...
متن کاملSwine by the Plasma Clearance of Iohexol
There is no simple method to measure glomerular filtration rate (GFR) in swine, an 15 established model to study renal disease. We developed a protocol to measure GFR in conscious 16 swine with the plasma clearance of iohexol. We used two groups: testing and validation, of 8 17 animals each. Ten milliliters of iohexol (6.47 g) were injected by the marginal auricular vein and 18 blood samples (3...
متن کاملEvaluation of a single sampling method for estimation of plasma iohexol clearance in dogs and cats with various kidney functions.
Plasma iohexol clearance (PCio) is a practical method for measuring the glomerular filtration rate (GFR) in clinical settings. However, it is too time-consuming for routine application and requires hospitalization for at least half a day. Therefore, the development of a simpler procedure for plasma clearance is necessary to allow the frequent measurement of GFR in clinical settings. The purpose...
متن کاملConcordance Between Iothalamate and Iohexol Plasma Clearance.
To the Editor: Iohexol is regarded as an accurate filtration marker for measuring GFR. Recently, Soveri et al concluded that plasma clearance of iohexol could be considered a valid alternative to the gold standard, urinary clearance of inulin. Because inulin urinary clearance is cumbersome and costly, iohexol and iothalamate clearance have become popular in Europe and the United States, respect...
متن کاملValidation of a routine two‐sample iohexol plasma clearance assessment of GFR and an evaluation of common endogenous markers in a rat model of CKD
Endogenous markers of kidney function are insensitive to early declines in glomerular filtration rate (GFR) and in rodent models, validated, practical alternatives are unavailable. In this study, we determined GFR by modeling the plasma clearance of two compounds, iohexol and inulin, and compared the findings to common endogenous markers. All plasma clearance methods of both iohexol and inulin ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2007
ISSN: 0931-0509,1460-2385
DOI: 10.1093/ndt/gfm411